Clinical Trials and Research


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10. Boger RH, Bode-Boger SM, Kienke S, et al. Dietary L-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterol-fed rabbits.Atherosclerosis 1998 Jan;136(1) 67-77

11. Cheng JW, Balwin SN. L-Arginine in the management of cardiovascular diseases. Ann Pharmacother 2001 Jun;35(6):755-64

12. Tentolouris C, Tousoulis D, et al. L-Arginine in coronary atherosclerosis. Int J Cardiol 2000 Sep 15;75(2- 3):123-8

13. Wang B, Ho HV, et al. Regression of atherosclerosis. Circulation 1999;99(9):1236-41

14. Boger RH, Bode-Boger SM, et al. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol fed rabbits: comparison with lovastatin. Circulation 1997; 96(4):1282-90

15. Schuschke DA, Miller FN, Lominadze DG, Feldhoff RC. L-arginine restores cholesterol-attenuated micro vascular responses in the rat cremaster. Int J Micricirc Clin Exp 1994 Jul-Aug;14(4): 204-11

16. Orlandi A, Marcellini M Spagnoli LG. Aging influences development and progression of earl aortic atherosclerosis lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasac Biol 2000 Apr;20

17. Chong PH, Bachenheimer BS. Current, New and future treatments in dyslipidemia and atherosclerosis. Drugs 2000 Jul;60(1):55-93

18. Phivthong-ngam L, Bode-Boger SM, Boger RH, et al. Dietary L-arginine normalizes endothelial induced vascular contractions in cholesterol-fed rabbits. J Cardiovasc Pharmacol 1998 Aug;32(2): 300-7

19. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16

20. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelial-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996 April; 97(8): 1989-94

21. Cooke JP, Dzau J, Creager A. Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. Basic Res Cardiol 1991; 86 Suppl 2: 173-81

22. Fraser GE. Diet and coronary heart disease: beyond dietary fats and low-density-lipoprotein cholesterol. Am J Clin Nutr 1994 May;59(5 Suppl) 1117s-1142sand atherosclerosis. Drugs 2000 Jul;60(1):55-93

23. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11

24. Lerman A, Burnett JC Jr, Higano ST, et al. Long-term L-arginine supplementation improves small vessel coronary endothelial function in humans. Circulation 1998 Jun 2;97(21):1648-9

25. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol 1997 Aug 1; 80(3):331-3

26. Desrois M, Sciaky M, Lan C, et al. L-arginine during long-term ischemia: effects on cardiac function, energetic metabolism and endothelial damage. J Heart Lung Transplant 2000 April; 19(4): 367-76

27. Quyyumi AA, Dakak N, Dodati JG, et al. Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilation, J AM Coll Cardiol 1997 Nov 1; 30(5):1220-7

28. Egashira K, et al. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation 1996;94(2):130-4

29. Tentoluris C, et al. L-arginine in coronary atherosclerosis. Int J Cardiol 2000 Sep15;75(2-3):123-8

30. Tretjakovs P, Kalnins U, Dabina I, et al. Plasma HDL-cholesterol has an effect on nitric oxide production and arachidonic production in the platelet membranes of coronary artery disease patients without LDLhypercholesterolemia. Med Sci Monitor 2000 May- Jun;6(3):507-11

31. Bode-Boger SM, Boger RH, Galland A, Tsikas D Frolich JC. L-arginine induced vasodilatation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998 Nov; 46(5): 489-97

32. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996 Oct;126(10):2563-7

33. Boger RH, Bode-Boger SM, Theil W, et al. Restoring vascular nitric oxide formation by L-arginine improves symptoms of intermittent claudication in patients with Peripheral arterial occlusive disease. J Am Col Cardiol 1998 Nov;32(5):1336-44

34. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19

35. Hiatt WR. New treatment options in intermittent claudication: the US experience. Int J Clin Pract Suppl 2001 Apr;(119):20-27

36. Creager MA. Medical management of peripheral artery disease. Cardiol Rev 2001 Jul-Aug;9(4):238-45

37. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A randomized double-blind study of oral Larginine for treatment of interstitial cystitis. J Urol 1999 Feb; 161(2):558-65

38. Cartledge JJ, Davies AM, Eardley I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU Int 2000 Mar; 85(4):421-6

39. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1 Pt 2):451-5

40. Higashi Y, et al. Effects of L-arginine infusion on renal hemodynamics in patients with mild hypertension. Hypertension1995;25(4):898-902

41. Hishikawa K, et al. Role of L-arginine-nitric oxide pathway in hypertension. J Hypertens 1993 Jun; 11(6):639-45

42. Dominiczak AF, Bohr DF. Nitric oxide and its’ putative role in hypertension. Hypertension 1995;25(6):1202-11

43. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7

44. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):428-33

45. Ghigo E, Aimaretti G, Cornelli G, et al. Diagnosis of GH deficiency in adults. Growth Hormone IGF Res 1998 Feb;8 Suppl A:55-8

46. Wideman L Weltman JY, Patrie JY, et al. Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise. Am J Physiol Regul Integr Comp Physiol 2000 Oct;279(4):R1467-77

47. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8

48. Mauras N, Walton P, Nicar M, et al. Growth hormone stimulation testing in both short and normal statured children. Pediatr Res 2000 Nov;48(5):579-80

49. Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth hormone-insulin-like growth facto-1 axis across the human life span. J Pediatr Endocrinol Metab 2000;13 Suppl 6:1493-502

50. Korbonits M, Kaltsas G, Perry LA, et al. The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. J Clin Endocrinol Metab 1999 Jul;84(7):2489-95

51. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8

52. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int 1999 Feb;83(3):269-73

53. Kobayashi N, Nakamura M, Hiramori K. Effects of infusion of L-arginine on exercise-induced myocardial ischemic changes and capacity to exercise of patients with stable angina pectoris. Coron Artery Dis 1999 Jul;10(5):321-6

54. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercised induced QT dispersion and exercise tolerance in stable angina pectoris.Int J Cardiol 2000 Sep 15; 75(2-3): 205-10

55. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int 1999 Aug;56(2):674-84

56. Watanabe G, Tomiyama H, Doba N. Effects of oral L-arginine on renal function in patients with heart failure. J Hypertens 2000 Feb;18(2):229-34

57. Kelly BS, Alexander JW Dreyer D, et al. Oral arginine improves blood pressure in renal transplant and hemodialysis patients. J Parenter Enteral Nutr 2001 Jul-Aug; 25(4): 194-202

58. Efron DT, Barbul A. Arginine and nutrition in renal disease. J Ren Nutr 1999 Jul;9(3):142-4

59. Reckelhoff JF, et al. Long-term dietary supplementation with L-arginine prevents age related reduction in renal function. Am J Physiol 1997 Jun; 272(6 Pt 2):1768-74

60.Reyes AA, Purkerson ML, Karl L, Klahr S. Dietary supplementation with L-arginine ameliorates the progression of renal disease in rats with subtotal nephrectomy. Am J Kidney Dis 1992 Aug; 20(2):454-5

61. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 1999 Sep; 48(9):1815-21

62. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax 1999 Nov;54(11):1033-5

63. De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol 2001 Feb;90(2):586-92

64. Boer J, et al. Role of L-arginine deficiency of nitric oxide and airway hyperreactivity after allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 Nov;128(5):1114-20

65. Blease K, Kunkel SL, Hogaboam CM. Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murinemodel of fungal asthma. Inflamm Res 2000 Jun; 49(6):297-304

66. Du J, Cui D, Tian D. [ The role of nitric oxide in the pathogenesis of asthma.] [ Full text in Chinese] Zhonghua Jie He He Hu Xi Za Zhi 1997 Jun;20(3):153-6

67. Gionotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA enriched enteral diet: effect on host response and nutritional status. J Parenter Enteral Nutr1999 Nov- Dec;23(6):314-20

68. Efron D, Barbul A. Role of arginine in immunonutrition. J Gastroentol 2000;35 Suppl 12:20-3

69.Lewis B, Langkamp-Henken B. Arginine enhances in vivo immune responses in young, adult and aged mice. J Nutri 2000;130(7):1827-30

70. Mannick JB, et al. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 1994 Dec 30;79(7):1137-46

71.Ochoa JB, et al. Effects of L-arginine on the proliferation of T-lymphocyte subpopulations. J Parenter Enteral Nutr 2001 Jan-Feb;25(1):23-9

72. di Luigi L, Guidetti L, Pigozzi F, et al. Acute amino acid supplementation enhances pituitary responsiveness in athletes. Med Sci Sports Exerc 1999 Dec;31(12):1748-54

73. Lawecki J et al. Serum insulin, pancreatic glucagons and growth hormone levels in response to intravenous infusion of L-arginine in patients with recently detected juvenile diabetes. Pol Med Sci Hist Bull 1976 Apr- Jun;15(2):177-82

74. Valcenti S, et al Biphasic effect of nitric oxide on testosterone and cyclic GMP productionby purified rat Leydig cells cultured in vivo. Int J Androl 1999 Oct; 22(5):336-41

75. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc 2000 Dec;32(12):2102-8

76. Piatti PM, Monti LD, Valsecchi G, et al. Long term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetes. Diabetes Care 2001 MAY;24(5):875-80

77. Giugliana D, et al. Vascular effects of acute hyperglycemia are reversed by L-arginine. Circulation 1997; 95(7):1783-90

78. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med 1998 Nov 1;25(7):757-65

79. Mendez JD, Balderas F. Regulation of hyperglycemia and dyslipidemia by exogenous L-arginine in Diabetic rats. Biochemie 2001 May;83(5):453-8

80. Kaposzta Z, et al. L-arginine and S-nitroglutathione reduce embolization in Humans. Circulation 2001;103(19):2371-75

81. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150

82. Wolf A, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997 Mar 1; 29(3):479

83. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82

84. Janero DR, Ewing JF. Nitric Oxide and Postangioplasty re-stenosis: Pathologicalcorrelates and therapeutic potential. Free Radic Biol Med 2000 Dec 15;29(12):1199-221/login?_sid=pA9K2IlHelvFq5Sm39sxDVozX3 gt;

85. Severin P, et al. Local intramural delivery of l-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Circulation 1997;95(7):1863-9

86. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32

87.Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses.. Methods Find Exp Clin Pharmacol 2001 Jan- Feb;23(1):13-7

88. Fini M, et al. Effect of l-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats Biomed Pharmacother 2001 May;55(4):213-21

89. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate 2001 Jun 15;48(1):40-6

90. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9

91. Koglin J. Pathogenetic mechanisms of cardiac allograft vasculopathy-impact of nitric oxide. Z Kardiol 2000;89 Suppl 9:IX/24-7

92. Kown MH, Van Der Steenhoven T, Uemura S, et al. L-Arginine polymer mediated inhibition of graft coronary artery disease after cardiac transplantation. Transplantation 2001 June 15;71(11):1542-8

93. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma. Lancet 1999 Aug 28:354;739

94. Morric CR, Kuypers FA, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Ped Hemat/Onc 2000 Nov-Dec;22(6):515-20

95. Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Med Sci Monitor 2000 Sep-Oct;6(5):901-7

96. Nagaya N, Uematsu M, et al. Short term oral administration of l-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med 2001 April;163(4):887-91

97. Barbul A, et al. Arginine enhances wound healing and lymphocyte immune responsesin humans. Surgery 1990 Aug;108(2):331-6; discussion 336-7

98. Kirk SJ, et al Arginine stimulates wound healing and immune function in elderly humans. Surgery 1993 Aug;114(2):155-9; discussion 160

99. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J of Nutri 1998 May;128(5):797-803

100. Blum A, Cannon RO, Costello R, et al. Endocrine and lipid effects of oral L-arginine treatment in healthy postmenopausal women. J Lab Clin Med 2000 Mar;135(3):231-7

101.Ohta Y, Nishida K., Protective effect of l-arginine against stress-induced gastric mucosal lesions in rats and its relation to nitric acid-mediated inhibition of neutrophil infiltration. Pharmacal Res 2001 Jun;43(6):535-41

102. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7

103. Calver A, Collier J, Vallance P. Dilator actions of arginine in human peripheral vasculature. Clin Sci 1991 Nov;81(5):695-700

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105. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.

106. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13

107. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colo-rectal cancer. Br J Surg 1997 Feb;84(2):238-41

108. Brittenden J, et al. Dietary supplementation with L-arginine in patients with breast cancer(> 4cm.) receiving multi-modality treatment: report of a feasibility study. Br J Cancer 1994 May;69(5):918-21

109. McCarty MF. Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer’s disease by suppressing synthesis of acute-phase cytokines. Med Hypotheses 1999 Nov;53(3):369-74

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111. de la Torre JC, Stefano GB. Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res Brain Res Rev 2000 Dec;34(3):119-36

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113. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses 1994 Jun;42(6):363-6

114. Pandhi P, Balakrishnan S. Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide. Indian J Physiol Pharmacol 1999 Jul; 43(3):378-82

115. Pendergast MA, et al. Nitric oxide synthase inhibition impairs delayed recall in mature monkeys. Pharmacol Biochem Behav 1997 Jan;56(1):81-7

116. Fideieff HL,et al. Reproducibility and safety of the arginine test in normal adults.Medicina (B Aires) 1999; 59(3):249-53

117. Fagan JM, et al. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 1999 Jan 8; 254(1):100-3

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