Clinical Trials and Research

 

1. Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner Books, 1999.

2. Coffee, C J: Metabolism. Madison, Ct: Fence Creek Publishing, 1998.pp388-389

3. Catt KJ: Molecular Mechanisms of Hormone Action. In Endocrinology and Metabolism, 3rd ed. Edited by Felig P,Baxter JD, Frohman LA. New York, NY: McGraw-Hill, 1995, pp 138-139

4. Gerhard M, et al. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 1996 Apr;27(4):849-53

5. Toprakci M, et al. Age-associated changes in nitric oxide metabolites, nitrite and nitrate. Int J Clin Lab Res 2000;30(2):83-5

6. Sakuma I, et al. Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc Natl Acad Sci USA 1988 Nov;85(22):8664-7

7.Vallance P, Moncada S. Nitric Oxide—from mediator to medicines. J R Coll Physicians Lond 1994 May-Jun;28 (3): 209-219

8. Kam PC, Govender G. Nitric oxide: basic science and clinical applications. Anaesthesia 1994 Jun;49(6): 515-21

9. Sinha G. Viagra: ups and downs. Popular Science 2000 July: page 35

10. Boger RH, Bode-Boger SM, Kienke S, et al. Dietary L-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterol-fed rabbits.Atherosclerosis 1998 Jan;136(1) 67-77

11. Cheng JW, Balwin SN. L-Arginine in the management of cardiovascular diseases. Ann Pharmacother 2001 Jun;35(6):755-64

12. Tentolouris C, Tousoulis D, et al. L-Arginine in coronary atherosclerosis. Int J Cardiol 2000 Sep 15;75(2- 3):123-8

13. Wang B, Ho HV, et al. Regression of atherosclerosis. Circulation 1999;99(9):1236-41

14. Boger RH, Bode-Boger SM, et al. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol fed rabbits: comparison with lovastatin. Circulation 1997; 96(4):1282-90

15. Schuschke DA, Miller FN, Lominadze DG, Feldhoff RC. L-arginine restores cholesterol-attenuated micro vascular responses in the rat cremaster. Int J Micricirc Clin Exp 1994 Jul-Aug;14(4): 204-11

16. Orlandi A, Marcellini M Spagnoli LG. Aging influences development and progression of earl aortic atherosclerosis lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasac Biol 2000 Apr;20

17. Chong PH, Bachenheimer BS. Current, New and future treatments in dyslipidemia and atherosclerosis. Drugs 2000 Jul;60(1):55-93

18. Phivthong-ngam L, Bode-Boger SM, Boger RH, et al. Dietary L-arginine normalizes endothelial induced vascular contractions in cholesterol-fed rabbits. J Cardiovasc Pharmacol 1998 Aug;32(2): 300-7

19. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16

20. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelial-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996 April; 97(8): 1989-94

21. Cooke JP, Dzau J, Creager A. Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. Basic Res Cardiol 1991; 86 Suppl 2: 173-81

22. Fraser GE. Diet and coronary heart disease: beyond dietary fats and low-density-lipoprotein cholesterol. Am J Clin Nutr 1994 May;59(5 Suppl) 1117s-1142sand atherosclerosis. Drugs 2000 Jul;60(1):55-93

23. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11

24. Lerman A, Burnett JC Jr, Higano ST, et al. Long-term L-arginine supplementation improves small vessel coronary endothelial function in humans. Circulation 1998 Jun 2;97(21):1648-9

25. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol 1997 Aug 1; 80(3):331-3

26. Desrois M, Sciaky M, Lan C, et al. L-arginine during long-term ischemia: effects on cardiac function, energetic metabolism and endothelial damage. J Heart Lung Transplant 2000 April; 19(4): 367-76

27. Quyyumi AA, Dakak N, Dodati JG, et al. Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilation, J AM Coll Cardiol 1997 Nov 1; 30(5):1220-7

28. Egashira K, et al. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation 1996;94(2):130-4

29. Tentoluris C, et al. L-arginine in coronary atherosclerosis. Int J Cardiol 2000 Sep15;75(2-3):123-8

30. Tretjakovs P, Kalnins U, Dabina I, et al. Plasma HDL-cholesterol has an effect on nitric oxide production and arachidonic production in the platelet membranes of coronary artery disease patients without LDLhypercholesterolemia. Med Sci Monitor 2000 May- Jun;6(3):507-11

31. Bode-Boger SM, Boger RH, Galland A, Tsikas D Frolich JC. L-arginine induced vasodilatation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998 Nov; 46(5): 489-97

32. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996 Oct;126(10):2563-7

33. Boger RH, Bode-Boger SM, Theil W, et al. Restoring vascular nitric oxide formation by L-arginine improves symptoms of intermittent claudication in patients with Peripheral arterial occlusive disease. J Am Col Cardiol 1998 Nov;32(5):1336-44

34. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19

35. Hiatt WR. New treatment options in intermittent claudication: the US experience. Int J Clin Pract Suppl 2001 Apr;(119):20-27

36. Creager MA. Medical management of peripheral artery disease. Cardiol Rev 2001 Jul-Aug;9(4):238-45

37. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A randomized double-blind study of oral Larginine for treatment of interstitial cystitis. J Urol 1999 Feb; 161(2):558-65

38. Cartledge JJ, Davies AM, Eardley I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU Int 2000 Mar; 85(4):421-6

39. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1 Pt 2):451-5

40. Higashi Y, et al. Effects of L-arginine infusion on renal hemodynamics in patients with mild hypertension. Hypertension1995;25(4):898-902

41. Hishikawa K, et al. Role of L-arginine-nitric oxide pathway in hypertension. J Hypertens 1993 Jun; 11(6):639-45

42. Dominiczak AF, Bohr DF. Nitric oxide and its’ putative role in hypertension. Hypertension 1995;25(6):1202-11

43. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7

44. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):428-33

45. Ghigo E, Aimaretti G, Cornelli G, et al. Diagnosis of GH deficiency in adults. Growth Hormone IGF Res 1998 Feb;8 Suppl A:55-8

46. Wideman L Weltman JY, Patrie JY, et al. Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise. Am J Physiol Regul Integr Comp Physiol 2000 Oct;279(4):R1467-77

47. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8

48. Mauras N, Walton P, Nicar M, et al. Growth hormone stimulation testing in both short and normal statured children. Pediatr Res 2000 Nov;48(5):579-80

49. Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth hormone-insulin-like growth facto-1 axis across the human life span. J Pediatr Endocrinol Metab 2000;13 Suppl 6:1493-502

50. Korbonits M, Kaltsas G, Perry LA, et al. The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. J Clin Endocrinol Metab 1999 Jul;84(7):2489-95

51. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8

52. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int 1999 Feb;83(3):269-73

53. Kobayashi N, Nakamura M, Hiramori K. Effects of infusion of L-arginine on exercise-induced myocardial ischemic changes and capacity to exercise of patients with stable angina pectoris. Coron Artery Dis 1999 Jul;10(5):321-6

54. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercised induced QT dispersion and exercise tolerance in stable angina pectoris.Int J Cardiol 2000 Sep 15; 75(2-3): 205-10

55. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int 1999 Aug;56(2):674-84

56. Watanabe G, Tomiyama H, Doba N. Effects of oral L-arginine on renal function in patients with heart failure. J Hypertens 2000 Feb;18(2):229-34

57. Kelly BS, Alexander JW Dreyer D, et al. Oral arginine improves blood pressure in renal transplant and hemodialysis patients. J Parenter Enteral Nutr 2001 Jul-Aug; 25(4): 194-202

58. Efron DT, Barbul A. Arginine and nutrition in renal disease. J Ren Nutr 1999 Jul;9(3):142-4

59. Reckelhoff JF, et al. Long-term dietary supplementation with L-arginine prevents age related reduction in renal function. Am J Physiol 1997 Jun; 272(6 Pt 2):1768-74

60.Reyes AA, Purkerson ML, Karl L, Klahr S. Dietary supplementation with L-arginine ameliorates the progression of renal disease in rats with subtotal nephrectomy. Am J Kidney Dis 1992 Aug; 20(2):454-5

61. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 1999 Sep; 48(9):1815-21

62. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax 1999 Nov;54(11):1033-5

63. De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol 2001 Feb;90(2):586-92

64. Boer J, et al. Role of L-arginine deficiency of nitric oxide and airway hyperreactivity after allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 Nov;128(5):1114-20

65. Blease K, Kunkel SL, Hogaboam CM. Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murinemodel of fungal asthma. Inflamm Res 2000 Jun; 49(6):297-304

66. Du J, Cui D, Tian D. [ The role of nitric oxide in the pathogenesis of asthma.] [ Full text in Chinese] Zhonghua Jie He He Hu Xi Za Zhi 1997 Jun;20(3):153-6

67. Gionotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA enriched enteral diet: effect on host response and nutritional status. J Parenter Enteral Nutr1999 Nov- Dec;23(6):314-20

68. Efron D, Barbul A. Role of arginine in immunonutrition. J Gastroentol 2000;35 Suppl 12:20-3

69.Lewis B, Langkamp-Henken B. Arginine enhances in vivo immune responses in young, adult and aged mice. J Nutri 2000;130(7):1827-30

70. Mannick JB, et al. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 1994 Dec 30;79(7):1137-46

71.Ochoa JB, et al. Effects of L-arginine on the proliferation of T-lymphocyte subpopulations. J Parenter Enteral Nutr 2001 Jan-Feb;25(1):23-9

72. di Luigi L, Guidetti L, Pigozzi F, et al. Acute amino acid supplementation enhances pituitary responsiveness in athletes. Med Sci Sports Exerc 1999 Dec;31(12):1748-54

73. Lawecki J et al. Serum insulin, pancreatic glucagons and growth hormone levels in response to intravenous infusion of L-arginine in patients with recently detected juvenile diabetes. Pol Med Sci Hist Bull 1976 Apr- Jun;15(2):177-82

74. Valcenti S, et al Biphasic effect of nitric oxide on testosterone and cyclic GMP productionby purified rat Leydig cells cultured in vivo. Int J Androl 1999 Oct; 22(5):336-41

75. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc 2000 Dec;32(12):2102-8

76. Piatti PM, Monti LD, Valsecchi G, et al. Long term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetes. Diabetes Care 2001 MAY;24(5):875-80

77. Giugliana D, et al. Vascular effects of acute hyperglycemia are reversed by L-arginine. Circulation 1997; 95(7):1783-90

78. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med 1998 Nov 1;25(7):757-65

79. Mendez JD, Balderas F. Regulation of hyperglycemia and dyslipidemia by exogenous L-arginine in Diabetic rats. Biochemie 2001 May;83(5):453-8

80. Kaposzta Z, et al. L-arginine and S-nitroglutathione reduce embolization in Humans. Circulation 2001;103(19):2371-75

81. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150

82. Wolf A, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997 Mar 1; 29(3):479

83. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82

84. Janero DR, Ewing JF. Nitric Oxide and Postangioplasty re-stenosis: Pathologicalcorrelates and therapeutic potential. Free Radic Biol Med 2000 Dec 15;29(12):1199-221/login?_sid=pA9K2IlHelvFq5Sm39sxDVozX3 gt;

85. Severin P, et al. Local intramural delivery of l-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Circulation 1997;95(7):1863-9

86. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32

87.Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses.. Methods Find Exp Clin Pharmacol 2001 Jan- Feb;23(1):13-7

88. Fini M, et al. Effect of l-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats Biomed Pharmacother 2001 May;55(4):213-21

89. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate 2001 Jun 15;48(1):40-6

90. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9

91. Koglin J. Pathogenetic mechanisms of cardiac allograft vasculopathy-impact of nitric oxide. Z Kardiol 2000;89 Suppl 9:IX/24-7

92. Kown MH, Van Der Steenhoven T, Uemura S, et al. L-Arginine polymer mediated inhibition of graft coronary artery disease after cardiac transplantation. Transplantation 2001 June 15;71(11):1542-8

93. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma. Lancet 1999 Aug 28:354;739

94. Morric CR, Kuypers FA, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Ped Hemat/Onc 2000 Nov-Dec;22(6):515-20

95. Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Med Sci Monitor 2000 Sep-Oct;6(5):901-7

96. Nagaya N, Uematsu M, et al. Short term oral administration of l-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med 2001 April;163(4):887-91

97. Barbul A, et al. Arginine enhances wound healing and lymphocyte immune responsesin humans. Surgery 1990 Aug;108(2):331-6; discussion 336-7

98. Kirk SJ, et al Arginine stimulates wound healing and immune function in elderly humans. Surgery 1993 Aug;114(2):155-9; discussion 160

99. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J of Nutri 1998 May;128(5):797-803

100. Blum A, Cannon RO, Costello R, et al. Endocrine and lipid effects of oral L-arginine treatment in healthy postmenopausal women. J Lab Clin Med 2000 Mar;135(3):231-7

101.Ohta Y, Nishida K., Protective effect of l-arginine against stress-induced gastric mucosal lesions in rats and its relation to nitric acid-mediated inhibition of neutrophil infiltration. Pharmacal Res 2001 Jun;43(6):535-41

102. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7

103. Calver A, Collier J, Vallance P. Dilator actions of arginine in human peripheral vasculature. Clin Sci 1991 Nov;81(5):695-700

104. Bode-Boger SM, Boger RH,et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996 Jan 1; 93(1):85-90

105. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.

106. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13

107. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colo-rectal cancer. Br J Surg 1997 Feb;84(2):238-41

108. Brittenden J, et al. Dietary supplementation with L-arginine in patients with breast cancer(> 4cm.) receiving multi-modality treatment: report of a feasibility study. Br J Cancer 1994 May;69(5):918-21

109. McCarty MF. Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer’s disease by suppressing synthesis of acute-phase cytokines. Med Hypotheses 1999 Nov;53(3):369-74

110. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord 2000 Nov- Dec;11(6):322-6

111. de la Torre JC, Stefano GB. Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res Brain Res Rev 2000 Dec;34(3):119-36

112. Kuiper MA, et al. Decrease cerebrospinal fluid nitrate levels in Parkinson’s disease, Alzheimer’s disease and multiple system atrophy patients. J Neurol Sci 1994 Jan; 121(1):46-9

113. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses 1994 Jun;42(6):363-6

114. Pandhi P, Balakrishnan S. Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide. Indian J Physiol Pharmacol 1999 Jul; 43(3):378-82

115. Pendergast MA, et al. Nitric oxide synthase inhibition impairs delayed recall in mature monkeys. Pharmacol Biochem Behav 1997 Jan;56(1):81-7

116. Fideieff HL,et al. Reproducibility and safety of the arginine test in normal adults.Medicina (B Aires) 1999; 59(3):249-53

117. Fagan JM, et al. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 1999 Jan 8; 254(1):100-3

118. Nitric oxide and pulmonary hypertension. Coron Artery Dis 1999 Jul; 10(5):287-94

119.      Baggio E, Gandini R, Plancher AC, Passeri M, Carmosino G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med. 1994;15 Suppl:s287-94.

120. Berman M, Erman A, Ben-Gal T, Dvir D, Georghiou GP, Stamler A, Vered Y, Vidne BA, Aravot D. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol. 2004 May;27(5):295-9.

121.      Yalcin A, Kilinc E, Sagcan A, Kultursay H. Coenzyme Q10 concentrations in coronary artery disease. Clin Biochem. 2004 Aug;37(8):706-9.

122.      Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, Hypertension and heart failure. Biofactors. 2003;18(1-4):91-100.

123.      Wilburn AJ, King DS, Glisson J, Rockhold RW, Wofford MR. The natural treatment of hypertension. J Clin Hypertens (Greenwich). 2004 May;6(5):242-8.

124.      Portakal O, Ozkaya O, Erden Inal M, Bozan B, Kosan M, Sayek I. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem. 2000 Jun;33(4):279-84.

125.  Quiles JL, Farquharson AJ, Ramirez-Tortosa MC, Grant I, Milne L, Huertas JR, Battino M, Mataix J, Wahle KW. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals  production in malignant and non-malignant prostate cells. Biofactors. 2003;18(1-4):265-70.

126.      Shekelle P, Hardy ML, Coulter I, Udani J, Spar M, Oda K, Jungvig LK, Tu W, Suttorp MJ, Valentine D, Ramirez L, Shanman R, Newberry SJ. Effect of the supplemental use of antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cancer. Evid Rep Technol Assess (Summ). 2003 Oct;(75):1-3.

127.      Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer’s and Parkinson’s diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembr. 2004 Aug;36(4):381-6.

128.  Roffe L, Schmidt K, Ernst E. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J Clin Oncol. 2004 Nov 1;22(21):4418-24.

129.  Ulm G. Differential therapy of advanced Parkinson’s disease with special reference to complementary therapeutic approaches. Schweiz Rundsch Med
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133. Sena CM, Nunes E, Gomes A, Santos MS, Proença T, Martins MI, Seiça RM. Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated Hemoglobin level and lipid peroxidation in pancreas of diabetic rats. Nutr Res. 2008 Feb;28(2):113-21.
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135. Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000 Oct;48(10):4581-9.

136. Singh RP, Chidambara Murthy KN, Jayaprakasha GK. Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem. 2002 Jan 2;50(1):81-6.

137. Ignarro LJ, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol. 1999 Dec;34(6):879-86.

138. de Nigris F, Williams-Ignarro S, Botti C, Sica V, Ignarro LJ, Napoli C. Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells. Nitric Oxide. 2006 Nov;15(3):259-63.

139. Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide. 2006 Sep;15(2):93-102.

140. de Nigris F, Williams-Ignarro S, Sica V, et al. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res. 2006 Sep 1; [Epub ahead of print].

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144. Aviram M, Hardak E, Vaya J, et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation. 2000 May 30;101(21):2510-7.

145. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8.

146. Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA. 2005 Oct 11;102(41):14813-8.

147. Pantuck AJ, Leppert JT, Zomorodian N, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res. 2006 Jul 1;12(13):4018-26.

148. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci. 2004 Jun;95(6):481-6.

149. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem. 2006 Feb 8;54(3):980-5.

150. Seeram NP, Adams LS, Henning SM, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7.

151. Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis. 2006 Aug 18; [Epub ahead of print].

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